Pantethine

Pantethine

SCHEMBL9112817

CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO.CCO

nearest known ligand 0.54

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Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Pantethine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.54
KCNH2 Q12809 1/20 0.54
VNN1 O95497 13/20 0.49
ZDHHC20 Q5W0Z9 1/20 0.39
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CHAT P28329 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pantethine SCHEMBL19544641 0.97 PTGS1 (0.56) PTGS1KCNH2VNN1ZDHHC20ALDH1A1
Pantethine SCHEMBL1650348 0.97 PTGS1 (0.56) PTGS1KCNH2VNN1ZDHHC20ALDH1A1
Pantethine SCHEMBL59597 0.97 PTGS1 (0.56) PTGS1KCNH2VNN1ZDHHC20ALDH1A1
Pantethine SCHEMBL8416070 0.96 PTGS1 (0.55) PTGS1KCNH2VNN1ZDHHC20ALDH1A1
Pantethine SCHEMBL19358994 0.96 PTGS1 (0.55) PTGS1KCNH2VNN1ZDHHC20ALDH1A1
Pantethine SCHEMBL19359043 0.96 PTGS1 (0.55) PTGS1KCNH2VNN1ZDHHC20ALDH1A1
SCHEMBL25747324 0.95 PTGS1 (0.51) PTGS1KCNH2VNN1ZDHHC20ALDH1A1
SCHEMBL18314794 0.95 PTGS1 (0.51) PTGS1KCNH2VNN1ZDHHC20ALDH1A1
Pantethine SCHEMBL9115760 0.94 PTGS1 (0.54) PTGS1KCNH2VNN1ZDHHC20ALDH1A1
Pantethine SCHEMBL8416043 0.93 PTGS1 (0.52) PTGS1KCNH2VNN1ZDHHC20ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995011673-A1 COMPOUNDS AND METHODS FOR TREATING SICKLE CELL ANEMIA OCULON CORPORATION (US) 1995-05-04 WO disclosed
WO-1995011884-A1 COMPOUNDS AND METHODS FOR INHIBITING CATARACT FORMATION OCULON CORPORATION (US) 1995-05-04 WO disclosed