Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.55 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.55 |
| ▸ | F3 | P13726 | 2/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9113056 | 1.00 | TDP1 (0.62) | TDP1GLAMAPTALDH1A1HDAC3 | |
| SCHEMBL4029202 | 0.88 | MAPT (0.64) | TDP1GLAMAPTALDH1A1HDAC3 | |
| SCHEMBL4023735 | 0.88 | MAPT (0.64) | TDP1GLAMAPTALDH1A1HDAC3 | |
| SCHEMBL11476916 | 0.80 | TDP1 (0.61) | TDP1GLAMAPTALDH1A1HDAC3 | |
| SCHEMBL11476908 | 0.80 | TDP1 (0.61) | TDP1GLAMAPTALDH1A1HDAC3 | |
| Butenone SCHEMBL28795707 | 0.79 | TDP1 (0.95) | TDP1GLAMAPTALDH1A1HDAC3 | |
| SCHEMBL16588259 | 0.78 | HDAC1 (0.61) | TDP1GLAMAPTALDH1A1HDAC3 | |
| Butenone SCHEMBL312972 | 0.77 | TDP1 (1.00) | TDP1GLAMAPTALDH1A1HDAC3 | |
| Butenone SCHEMBL12984182 | 0.77 | TDP1 (1.00) | TDP1GLAMAPTALDH1A1HDAC3 | |
| Butenone SCHEMBL76632 | 0.77 | TDP1 (1.00) | TDP1GLAMAPTALDH1A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670831-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995009159-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-04-06 | — | — | WO | disclosed |