Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 15/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL911455 | 1.00 | OPRK1 (0.59) | OPRK1KCNH2OPRM1SLC6A2SLC6A4 | |
| Trifluoroacetic Acid SCHEMBL911957 | 0.89 | OPRK1 (0.57) | OPRK1KCNH2OPRM1SLC6A2SLC6A4 | |
| Trifluoroacetic Acid SCHEMBL911959 | 0.89 | OPRK1 (0.57) | OPRK1KCNH2OPRM1SLC6A2SLC6A4 | |
| SCHEMBL911693 | 0.81 | SLC6A2 (0.59) | OPRK1KCNH2OPRM1SLC6A2SLC6A4 | |
| SCHEMBL911692 | 0.81 | SLC6A2 (0.59) | OPRK1KCNH2OPRM1SLC6A2SLC6A4 | |
| SCHEMBL1438129 | 0.75 | SLC6A4 (0.63) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29735165 | 0.75 | SLC6A4 (0.63) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3632732 | 0.74 | SLC6A2 (0.55) | OPRK1KCNH2OPRM1SLC6A2SLC6A4 | |
| SCHEMBL3632729 | 0.74 | SLC6A2 (0.55) | OPRK1KCNH2OPRM1SLC6A2SLC6A4 | |
| SCHEMBL911076 | 0.72 | SLC6A4 (0.88) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868017-B2 | 9-azabicyclo[3.3.1]nonane derivatives | N.V. ORGANON (NL) | 2011-01-11 | — | — | US | disclosed |
| US-7868017-B2 | 9-azabicyclo[3.3.1]nonane derivatives | N.V. ORGANON (NL) | 2011-01-11 | — | — | US | disclosed |
| US-7868017-B2 | 9-azabicyclo[3.3.1]nonane derivatives | N.V. ORGANON (NL) | 2011-01-11 | — | — | US | disclosed |
| US-20070112019-A1 | 9-Azabicyclo[3.3.1]nonane derivatives | N.V. ORGANON (NL) | 2007-05-17 | — | — | US | disclosed |
| US-20070112019-A1 | 9-Azabicyclo[3.3.1]nonane derivatives | N.V. ORGANON (NL) | 2007-05-17 | — | — | US | disclosed |
| US-20070112019-A1 | 9-Azabicyclo[3.3.1]nonane derivatives | N.V. ORGANON (NL) | 2007-05-17 | — | — | US | disclosed |
| WO-2007039563-A1 | 9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS | N.V. ORGANON (NL) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112019-A1 | 9-Azabicyclo[3.3.1]nonane derivatives | AZI2, TPMT, TET3 | OPRK1 3261/4885KCNH2 1556/4885OPRM1 3168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.