Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44355 | 0.93 | — | — | |
| Trifluoroacetic Acid SCHEMBL9618064 | 0.84 | GSTP1 (0.35) | TSHRGSTP1NPC1SLC1A3SLC1A2 | |
| SCHEMBL25284864 | 0.77 | TSHR (0.42) | TSHRGSTP1NPC1SLC1A3SLC1A2 | |
| SCHEMBL8430617 | 0.76 | TSHR (0.50) | TSHRGSTP1NPC1SLC1A3SLC1A2 | |
| SCHEMBL13314209 | 0.76 | — | — | |
| SCHEMBL4446043 | 0.74 | GSTP1 (0.53) | TSHRGSTP1NPC1SLC1A3SLC1A2 | |
| SCHEMBL10527889 | 0.74 | NPC1 (0.45) | TSHRGSTP1NPC1SLC1A3SLC1A2 | |
| SCHEMBL10010450 | 0.74 | — | — | |
| SCHEMBL1483317 | 0.72 | GSTP1 (0.57) | TSHRGSTP1ALDH1A1TAAR1POLB | |
| SCHEMBL14613083 | 0.72 | CYP1A2 (0.55) | TSHRGSTP1NPC1SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0671931-A4 | HEMOREGULATORY PEPTIDES. | SMITHKLINE BEECHAM CORP (US) | 1995-11-22 | — | — | EP | disclosed |
| EP-0671931-A1 | HEMOREGULATORY PEPTIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1993010807-A1 | HEMOREGULATORY PEPTIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-10 | — | — | WO | disclosed |