Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.66 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9117222 | 0.95 | PTGS2 (0.59) | PTGS2PTGS1CDK9GPR55CTSK | |
| SCHEMBL9117675 | 0.95 | PTGS2 (0.59) | PTGS2PTGS1CDK9GPR55CTSK | |
| SCHEMBL9119719 | 0.88 | PTGS2 (0.49) | PTGS2PTGS1CTSKPIK3CDPIP5K1C | |
| SCHEMBL9117193 | 0.88 | PTGS2 (0.49) | PTGS2PTGS1CTSKPIK3CDPIP5K1C | |
| SCHEMBL9117806 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL9117200 | 0.86 | PTGS2 (0.48) | PTGS2PTGS1CTSKPIK3CDPIP5K1C | |
| SCHEMBL8974381 | 0.86 | PTGS2 (0.47) | PTGS2PTGS1CDK9GPR55PIK3CD | |
| SCHEMBL9118890 | 0.86 | PTGS2 (0.48) | PTGS2PTGS1CTSKPIK3CDPIP5K1C | |
| SCHEMBL9237630 | 0.84 | PTGS2 (0.46) | PTGS2PTGS1CTSKPIK3CDPIP5K1C | |
| SCHEMBL9118861 | 0.84 | PTGS1 (0.46) | PTGS2PTGS1PIK3CDPIP5K1CPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | claimed |
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |