Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.64 |
| ▸ | CSF1R | P07333 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | KIF5B | P33176 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 8/20 | 0.51 |
| ▸ | BACE1 | P56817 | 8/20 | 0.51 |
| ▸ | KIT | P10721 | 4/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8644682 | 0.99 | EGFR (0.65) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL9052023 | 0.92 | EGFR (0.56) | EGFRCSF1RRETKDRKIF5B | |
| Hydrochloric Acid SCHEMBL9113512 | 0.92 | EGFR (0.56) | EGFRCSF1RRETKDRKIF5B | |
| Hydrochloric Acid SCHEMBL9114138 | 0.88 | KDM1A (0.54) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL9115476 | 0.87 | EGFR (0.64) | EGFRCSF1RRETKDRKIF5B | |
| Hydrochloric Acid SCHEMBL8647933 | 0.84 | EGFR (0.53) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8647385 | 0.82 | EGFR (0.73) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8650196 | 0.82 | EGFR (0.73) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL9056703 | 0.82 | EGFR (0.73) | EGFRCSF1RRETKDRKIF5B | |
| Hydrochloric Acid SCHEMBL8652234 | 0.81 | EGFR (0.74) | EGFRCSF1RRETKDRKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |