Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | AKT2 | P31751 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | EEF2K | O00418 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5631019 | 0.81 | HSP90AA1 (0.60) | HSP90AA1KDM4EHTTMEN1KMT2A | |
| SCHEMBL9118850 | 0.80 | ALDH1A1 (0.44) | KDM4EHTTMEN1KMT2ATSHR | |
| SCHEMBL9118401 | 0.79 | HSP90AA1 (0.56) | HSP90AA1KDM4EHTTMEN1KMT2A | |
| SCHEMBL9119941 | 0.76 | HSP90AA1 (0.75) | HSP90AA1KDM4EHTTMEN1KMT2A | |
| SCHEMBL9116312 | 0.73 | HSP90AA1 (0.57) | HSP90AA1KDM4EHTTMEN1KMT2A | |
| SCHEMBL3102522 | 0.73 | HSP90AA1 (0.83) | HSP90AA1KDM4EHTTMEN1KMT2A | |
| SCHEMBL5632986 | 0.73 | HSP90AA1 (0.83) | HSP90AA1KDM4EHTTMEN1KMT2A | |
| SCHEMBL29748943 | 0.73 | HSP90AA1 (0.83) | HSP90AA1KDM4EHTTMEN1KMT2A | |
| SCHEMBL29948904 | 0.73 | HSP90AA1 (0.83) | HSP90AA1KDM4EHTTMEN1KMT2A | |
| SCHEMBL5430208 | 0.72 | HSP90AA1 (0.73) | HSP90AA1KDM4EHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477819-B1 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-03-15 | — | — | EP | disclosed |
| US-5200422-A | Benzimidazole derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-04-06 | — | — | US | disclosed |
| EP-0477819-A2 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-04-01 | — | — | EP | disclosed |