Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Practolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 4/20 | 0.97 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.97 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | CNR1 | P21554 | 1/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Practolol SCHEMBL39925 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| Practolol SCHEMBL39926 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| Practolol SCHEMBL6509191 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL11884649 | 0.95 | ADRB2 (0.92) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31148312 | 0.88 | ADRB2 (0.76) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL14307663 | 0.86 | ADRB2 (0.78) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL21793189 | 0.85 | ADRB2 (0.76) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL11640326 | 0.85 | ADRB2 (0.76) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL11078398 | 0.85 | ADRB3 (0.75) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| Practolol SCHEMBL11383487 | 0.84 | ADRB2 (0.73) | ADRB2ADRB1ADRB3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995020568-A1 | PHARMACEUTICAL PRODUCT COMPRISING A SALICYLATE OF AN ESTERIFIABLE BETA-BLOCKER | CAL INTERNATIONAL LIMITED (IE) | 1995-08-03 | — | — | WO | disclosed |
| US-4161530-A | CYCLIC SUBSTITUTED AMINO ALCOHOL BETA-RECEPTOR-BLOCKING AGENT AND TRYPTOPHANE | CIBA-GEIGY CORPORATION (US) | 1979-07-17 | — | — | US | disclosed |