Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | PDE5A | O76074 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 9/20 | 0.42 |
| ▸ | PPARD | Q03181 | 9/20 | 0.42 |
| ▸ | PPARA | Q07869 | 9/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121837 | 0.93 | LMNA (0.48) | MAOBPDE5ALMNAGAAMAOA | |
| SCHEMBL8467032 | 0.89 | MAOB (0.48) | MAOBLMNAGAAMAOAMAPK14 | |
| SCHEMBL9118797 | 0.86 | MAOB (0.50) | MAOBLMNAGAAMAOAMAPK14 | |
| SCHEMBL8466028 | 0.82 | MAOB (0.46) | MAOBLMNAGAAMAOAMAPK14 | |
| SCHEMBL31632472 | 0.80 | MAOB (0.51) | MAOBLMNAGAAMAOAMAPK14 | |
| SCHEMBL9240243 | 0.79 | MAOB (0.44) | MAOBLMNAGAAMAOAMAPK14 | |
| SCHEMBL9191249 | 0.79 | MAOB (0.44) | MAOBLMNAGAAMAOAMAPK14 | |
| SCHEMBL10972035 | 0.78 | PDE5A (0.52) | PDE5APPARGPPARDPPARAP2RY12 | |
| SCHEMBL9122729 | 0.78 | PPARA (0.43) | PDE5APPARGPPARDPPARAP2RY12 | |
| SCHEMBL10975462 | 0.77 | PDE5A (0.51) | MAOBPDE5APPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |