Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 4/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119417 | 1.00 | CYP4F2 (0.50) | CYP4F2CYP4A11TSHRTDP1ALDH1A1 | |
| SCHEMBL27261890 | 0.87 | LIPG (0.51) | CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL22954711 | 0.86 | CYP4F2 (0.56) | CYP4F2CYP4A11TSHRTDP1ALDH1A1 | |
| SCHEMBL10438855 | 0.86 | CYP4F2 (0.58) | CYP4F2CYP4A11TSHRTDP1ALDH1A1 | |
| SCHEMBL9120993 | 0.86 | CYP4F2 (0.46) | CYP4F2CYP4A11TSHRTDP1ALDH1A1 | |
| SCHEMBL9120258 | 0.85 | CYP4F2 (0.46) | CYP4F2CYP4A11TSHRALDH1A1LMNA | |
| SCHEMBL11723225 | 0.84 | CYP4F2 (0.70) | CYP4F2CYP4A11TSHRALDH1A1LMNA | |
| SCHEMBL9122500 | 0.84 | PPARD (0.53) | ALDH1A1 | |
| SCHEMBL31076144 | 0.83 | CYP4F2 (0.53) | CYP4F2CYP4A11TSHRALDH1A1LMNA | |
| SCHEMBL5561929 | 0.83 | CYP4F2 (0.53) | CYP4F2CYP4A11TSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |