Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 10/20 | 0.44 |
| ▸ | CNR1 | P21554 | 6/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121261 | 0.88 | PDE3B (0.46) | MEN1ALDH1A1KMT2AMAPTCNR2 | |
| SCHEMBL27088423 | 0.88 | MEN1 (0.67) | MEN1ALDH1A1KMT2ACNR2CNR1 | |
| SCHEMBL9120001 | 0.86 | MEN1 (0.47) | MEN1ALDH1A1KMT2AMAPTCNR2 | |
| SCHEMBL9444512 | 0.86 | CNR2 (0.43) | MEN1ALDH1A1KMT2AMAPTCNR2 | |
| SCHEMBL8799495 | 0.86 | MEN1 (0.48) | MEN1ALDH1A1KMT2AMAPTCNR2 | |
| SCHEMBL9122500 | 0.81 | PPARD (0.53) | ALDH1A1PPARDLTB4RLTB4R2PPARG | |
| SCHEMBL31155834 | 0.80 | MEN1 (0.48) | MEN1ALDH1A1KMT2AMAPTCNR2 | |
| SCHEMBL5988709 | 0.80 | KMT2A (0.44) | MEN1ALDH1A1KMT2AMAPTCNR2 | |
| SCHEMBL9120954 | 0.79 | BRD4 (0.48) | MEN1KMT2ACNR2PDE3BPDE3A | |
| SCHEMBL9121657 | 0.78 | HDAC8 (0.53) | MAPTPDE3BPDE3AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |