Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 16/20 | 0.58 |
| ▸ | LTB4R2 | Q9NPC1 | 12/20 | 0.58 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119413 | 1.00 | LTB4R (0.58) | LTB4RLTB4R2CNR1CNR2CYP2C9 | |
| SCHEMBL9121682 | 1.00 | LTB4R (0.58) | LTB4RLTB4R2CNR1CNR2CYP2C9 | |
| SCHEMBL9121586 | 1.00 | LTB4R (0.58) | LTB4RLTB4R2CNR1CNR2CYP2C9 | |
| SCHEMBL9119987 | 1.00 | LTB4R (0.58) | LTB4RLTB4R2CNR1CNR2CYP2C9 | |
| SCHEMBL8463994 | 0.96 | LTB4R (0.54) | LTB4RLTB4R2CNR1CNR2CYP2C9 | |
| SCHEMBL9444467 | 0.94 | LTB4R (0.67) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL9122175 | 0.91 | LTB4R (0.52) | LTB4RLTB4R2CNR1CNR2CYP2C9 | |
| SCHEMBL6760695 | 0.89 | LTB4R (0.57) | LTB4RLTB4R2CYP2C9PPARG | |
| SCHEMBL9122731 | 0.89 | LTB4R (0.48) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8799670 | 0.89 | LTB4R (0.50) | LTB4RLTB4R2CNR1CNR2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |