Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 10/20 | 0.40 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9120082 | 0.85 | MEN1 (0.49) | MEN1KMT2ACNR2CNR1BRD4 | |
| SCHEMBL9121763 | 0.85 | MEN1 (0.45) | MEN1KMT2ACNR2CNR1BRD4 | |
| SCHEMBL9121754 | 0.85 | MEN1 (0.45) | MEN1KMT2ACNR2CNR1BRD4 | |
| SCHEMBL8463851 | 0.82 | LTB4R (0.44) | MEN1KMT2ACNR2CNR1LTB4R | |
| SCHEMBL9120964 | 0.81 | LTB4R (0.46) | MEN1KMT2ACNR2CNR1LTB4R | |
| SCHEMBL9121601 | 0.81 | LTB4R (0.46) | MEN1KMT2ACNR2CNR1LTB4R | |
| SCHEMBL9120015 | 0.81 | LTB4R (0.46) | MEN1KMT2ACNR2CNR1LTB4R | |
| SCHEMBL8463856 | 0.77 | CYP4F2 (0.41) | MEN1KMT2A | |
| SCHEMBL8003850 | 0.77 | MEN1 (0.48) | MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL9122251 | 0.76 | MEN1 (0.47) | MEN1KMT2ALTB4RLTB4R2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |