SCHEMBL9119239

SCHEMBL9119239

[CH2]CCCCN1C(=O)C2CCCCC2C1=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.43
HTR1A P08908 3/20 0.40
DRD2 P14416 2/20 0.40
HTR2A P28223 2/20 0.40
LMNA P02545 1/20 0.40
CHRM2 P08172 1/20 0.40
ADRA2A P08913 1/20 0.40
CHRM1 P11229 1/20 0.40
DRD1 P21728 1/20 0.40
TBXA2R P21731 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
ADRA1A P35348 1/20 0.40
OPRM1 P35372 1/20 0.40
DRD3 P35462 1/20 0.40
SLC6A3 Q01959 1/20 0.40
KCNH2 Q12809 1/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
ESR1 P03372 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1495371 0.98 ALDH1A1 (0.42) ALDH1A1HTR1ADRD2HTR2ALMNA
SCHEMBL17532423 0.88 ALDH1A1 (0.49) ALDH1A1HTR1ADRD2HTR2ALMNA
SCHEMBL10948563 0.88 ALDH1A1 (0.49) ALDH1A1HTR1ADRD2HTR2ALMNA
SCHEMBL17532416 0.86 ALDH1A1 (0.50) ALDH1A1HTR1ADRD2HTR2ALMNA
SCHEMBL17532412 0.81 ALDH1A1 (0.53) ALDH1A1KMT2AHTTRAB9ASMN1; SMN2
SCHEMBL9532032 0.81 ALDH1A1 (0.43) ALDH1A1HTR1ADRD2HTR2ALMNA
SCHEMBL11845960 0.81 CNR2 (0.46) ALDH1A1HTR1ALMNACHRM2ADRA2A
SCHEMBL14359600 0.81 ALDH1A1 (0.47) ALDH1A1HTR1ADRD2HTR2ALMNA
SCHEMBL28956491 0.81 ALDH1A1 (0.43) ALDH1A1HTR1ADRD2HTR2ALMNA
SCHEMBL11510536 0.78 HTT (0.51) ALDH1A1HTR1ALMNACHRM2ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0548664-B1 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives HOFFMANN LA ROCHE (CH) 1995-05-31 EP claimed
US-5318966-A Administering the enzyme inhibitor for treating alzheimer's disease, learning enhancement, brain disorders HOFFMANN-LA ROCHE INC. (US) 1994-06-07 US claimed
US-5318967-A Cognition activators for alzheimer's disease, learning enhancement HOFFMANN-LA ROCHE INC. (US) 1994-06-07 US claimed
EP-0548664-A1 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1993-06-30 EP claimed
EP-0548664-B1 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives HOFFMANN LA ROCHE (CH) 1995-05-31 EP disclosed
US-5318966-A Administering the enzyme inhibitor for treating alzheimer's disease, learning enhancement, brain disorders HOFFMANN-LA ROCHE INC. (US) 1994-06-07 US disclosed
US-5318967-A Cognition activators for alzheimer's disease, learning enhancement HOFFMANN-LA ROCHE INC. (US) 1994-06-07 US disclosed
EP-0548664-A1 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1993-06-30 EP disclosed