Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.45 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20872624 | 0.84 | OPRK1 (0.51) | OPRK1KDM4EMAPK1LMNASMN1; SMN2 | |
| SCHEMBL3108102 | 0.83 | TSHR (0.46) | KDM4EGLAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL12024798 | 0.81 | ATM (0.50) | ATMOPRK1CYP46A1KDM4EGLA | |
| SCHEMBL30294812 | 0.81 | OPRK1 (0.46) | OPRK1KDM4EGLAMAPK1LMNA | |
| SCHEMBL22288713 | 0.81 | OPRK1 (0.46) | ATMOPRK1KDM4EGLAMAPK1 | |
| SCHEMBL28956660 | 0.81 | KDM4E (0.45) | OPRK1KDM4EGLAMAPK1LMNA | |
| SCHEMBL28960417 | 0.81 | OPRK1 (0.46) | OPRK1KDM4EGLAMAPK1LMNA | |
| SCHEMBL19682934 | 0.81 | KDR (0.49) | OPRK1KDM4EMAPK1LMNAHTT | |
| SCHEMBL29833413 | 0.80 | ATM (0.49) | ATMOPRK1CYP46A1KDM4EGLA | |
| SCHEMBL2487068 | 0.80 | ATM (0.49) | ATMOPRK1CYP46A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023218023-A1 | THIAZOLOARYL-METHYL SUBSTITUTED CYCLIC HYDRAZINE-N-CARBOXAMIDE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-11-16 | — | — | WO | disclosed |
| US-5426089-A | Controlling undesired plant growth | SHELL RESEARCH LIMITED (GB) | 1995-06-20 | — | — | US | disclosed |
| EP-0434132-B1 | Herbicidal acrylonitrile derivatives | SHELL INT RESEARCH (NL) | 1995-04-05 | — | — | EP | disclosed |
| US-5366956-A | Herbicidal acrylonitrile derivatives | SHELL RESEARCH LIMITED (GB) | 1994-11-22 | — | — | US | disclosed |
| EP-0434132-A2 | Herbicidal acrylonitrile derivatives | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1991-06-26 | — | — | EP | disclosed |