Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 10/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8175020 | 1.00 | HSD11B1 (0.84) | HSD11B1ADRA1ADRD2HTR1AADRA2A | |
| SCHEMBL9119375 | 1.00 | HSD11B1 (0.84) | HSD11B1ADRA1ADRD2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL9441191 | 0.99 | HSD11B1 (0.82) | HSD11B1ADRA1ADRD2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL9121202 | 0.99 | HSD11B1 (0.82) | HSD11B1ADRA1ADRD2HTR1AADRA2A | |
| SCHEMBL1870138 | 0.92 | HSD11B1 (1.00) | HSD11B1ADRA1ADRD2HTR1A | |
| SCHEMBL9964002 | 0.92 | HSD11B1 (1.00) | HSD11B1ADRA1ADRD2HTR1A | |
| SCHEMBL1871835 | 0.92 | HSD11B1 (1.00) | HSD11B1ADRA1ADRD2HTR1A | |
| SCHEMBL1868061 | 0.92 | HSD11B1 (1.00) | HSD11B1ADRA1ADRD2HTR1A | |
| SCHEMBL15139395 | 0.92 | HSD11B1 (1.00) | HSD11B1ADRA1ADRD2HTR1A | |
| SCHEMBL1870135 | 0.92 | HSD11B1 (1.00) | HSD11B1ADRA1ADRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548664-B1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | HOFFMANN LA ROCHE (CH) | 1995-05-31 | — | — | EP | disclosed |
| US-5318967-A | Cognition activators for alzheimer's disease, learning enhancement | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5318966-A | Administering the enzyme inhibitor for treating alzheimer's disease, learning enhancement, brain disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0548664-A1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |