Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119464 | 0.96 | CYP19A1 (0.46) | CYP19A1ALDH1A1CNR1CNR2MITF | |
| SCHEMBL9641135 | 0.93 | CYP19A1 (0.56) | CYP19A1CYP17A1ALDH1A1CNR1CNR2 | |
| SCHEMBL9120327 | 0.84 | CYP19A1 (0.54) | CYP19A1CNR1CNR2 | |
| SCHEMBL4379246 | 0.83 | CYP19A1 (0.36) | CYP19A1ALDH1A1LMNAHTTHRH3 | |
| SCHEMBL9090383 | 0.83 | CYP19A1 (0.63) | CYP19A1MAPT | |
| SCHEMBL9119383 | 0.82 | CYP19A1 (0.43) | CYP19A1 | |
| SCHEMBL9120192 | 0.81 | CYP19A1 (0.54) | CYP19A1CNR1CNR2 | |
| SCHEMBL9119601 | 0.81 | CYP19A1 (0.54) | CYP19A1MAPK1 | |
| SCHEMBL7987297 | 0.81 | HRH3 (0.54) | ALDH1A1LMNAMAPK1NPSR1HRH3 | |
| SCHEMBL9120034 | 0.81 | CYP19A1 (0.50) | CYP19A1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0390558-B1 | Aromatase inhibiting 4(5)-imidazoles | ORION YHTYMAE OY (FI) | 1994-09-07 | — | — | EP | claimed |
| EP-0390558-A1 | Aromatase inhibiting 4(5)-imidazoles | ORION-YHTYMÀ OY (FI) | 1990-10-03 | — | — | EP | claimed |
| US-5439928-A | Enzyme inhibitors as antitumor agents for breast cancer | ORION-YHTYMA OY (FI) | 1995-08-08 | — | — | US | disclosed |
| EP-0390558-B1 | Aromatase inhibiting 4(5)-imidazoles | ORION YHTYMAE OY (FI) | 1994-09-07 | — | — | EP | disclosed |
| EP-0390558-A1 | Aromatase inhibiting 4(5)-imidazoles | ORION-YHTYMÀ OY (FI) | 1990-10-03 | — | — | EP | disclosed |