Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 16/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 16/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9123650 | 0.98 | HTR2A (0.64) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL8886798 | 0.83 | HTR2A (0.66) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL5836497 | 0.83 | HTR2A (0.68) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL641336 | 0.81 | SLC6A4 (0.63) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL756212 | 0.80 | DPP4 (0.50) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL9122819 | 0.79 | SLC6A4 (0.61) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL14397395 | 0.78 | HTR2A (0.58) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL1341069 | 0.77 | GAA (0.62) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| Pamoic Acid SCHEMBL9124358 | 0.77 | GPR35 (0.57) | HTR2ASLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL112757 | 0.77 | SLC6A2 (0.61) | SLC6A4SLC6A2SLC6A3DPP4PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516234-B1 | Phenoxyphenyl derivatives | AKZO NOBEL NV (NL) | 1995-09-13 | — | — | EP | claimed |
| US-5430063-A | Antidepressants | AKZO N.V. (NL) | 1995-07-04 | — | — | US | claimed |
| EP-0516234-A1 | Phenoxyphenyl derivatives | Akzo Nobel N.V. (NL) | 1992-12-02 | — | — | EP | claimed |
| EP-0516234-B1 | Phenoxyphenyl derivatives | AKZO NOBEL NV (NL) | 1995-09-13 | — | — | EP | disclosed |
| US-5430063-A | Antidepressants | AKZO N.V. (NL) | 1995-07-04 | — | — | US | disclosed |
| US-5190965-A | Treatment of depression | AKZO N.V. (NL) | 1993-03-02 | — | — | US | disclosed |
| EP-0516234-A1 | Phenoxyphenyl derivatives | Akzo Nobel N.V. (NL) | 1992-12-02 | — | — | EP | disclosed |