SCHEMBL9119848

SCHEMBL9119848

CNC(=O)Nc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)CC(C)(C)NCc3cc4ccccc4o3)CCc3ccccc32)cc1

nearest known ligand 0.54

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 4/20 0.54
AGTR1 P30556 1/20 0.49
NPY1R P25929 3/20 0.46
XIAP P98170 9/20 0.46
CCKBR P32239 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9108293 0.93 GHSR (0.56) GHSRAGTR1NPY1RXIAPCCKBR
SCHEMBL9103708 0.91 GHSR (0.67) GHSRAGTR1NPY1RXIAP
SCHEMBL9103783 0.88 GHSR (0.55) GHSRAGTR1NPY1RXIAP
SCHEMBL9030610 0.88 XIAP (0.42) GHSRAGTR1NPY1RXIAP
SCHEMBL9107964 0.87 GHSR (0.53) GHSRAGTR1NPY1RXIAP
SCHEMBL9104316 0.86 GHSR (0.54) GHSRAGTR1NPY1RXIAP
SCHEMBL9104324 0.86 GHSR (0.54) GHSRAGTR1NPY1RXIAP
SCHEMBL9102836 0.84 GHSR (0.55) GHSRAGTR1NPY1RXIAP
SCHEMBL7794301 0.84 GHSR (0.56) GHSRAGTR1NPY1RXIAP
SCHEMBL7792076 0.84 GHSR (0.56) GHSRAGTR1NPY1RXIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995003290-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1995-02-02 WO claimed