Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.72 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.66 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118096 | 0.94 | LTB4R (0.78) | LTB4RLTB4R2PRSS1PLA2G4BMAPT | |
| SCHEMBL9116641 | 0.90 | LTB4R (0.75) | LTB4RLTB4R2PRSS1PLA2G4BMAPT | |
| SCHEMBL9121805 | 0.90 | LTB4R (0.77) | LTB4RLTB4R2PRSS1RENPLA2G4B | |
| SCHEMBL9119186 | 0.89 | LTB4R (0.72) | LTB4RLTB4R2PRSS1RENPLA2G4B | |
| SCHEMBL9121783 | 0.87 | LTB4R (0.70) | LTB4RLTB4R2PRSS1RENPLA2G4B | |
| SCHEMBL9120860 | 0.87 | LTB4R (0.70) | LTB4RLTB4R2PRSS1PLA2G4BMAPT | |
| SCHEMBL9117208 | 0.86 | LTB4R (0.66) | LTB4RLTB4R2RENPLA2G4BMAPT | |
| SCHEMBL9120867 | 0.86 | LTB4R (0.74) | LTB4RLTB4R2PRSS1PLA2G4BMAPT | |
| SCHEMBL9120246 | 0.85 | LTB4R (0.67) | LTB4RLTB4R2PRSS1PLA2G4BMAPT | |
| Moxilubant SCHEMBL6439215 | 0.84 | LTB4R (1.00) | LTB4RLTB4R2PRSS1PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |