Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.68 |
| ▸ | CCKBR | P32239 | 10/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.60 |
| ▸ | PDE5A | O76074 | 2/20 | 0.59 |
| ▸ | PDE1A | P54750 | 2/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123005 | 0.89 | CCKBR (0.60) | PDE4APDE4BPDE4CPDE4DCCKBR | |
| SCHEMBL9122239 | 0.87 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DCCKBR | |
| SCHEMBL9226379 | 0.85 | CCKBR (0.61) | CCKBR | |
| SCHEMBL9123614 | 0.84 | CCKBR (0.68) | PDE4APDE4BPDE4CPDE4DCCKBR | |
| SCHEMBL14468290 | 0.83 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7499624 | 0.82 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7497465 | 0.82 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7493301 | 0.81 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCCKBR | |
| SCHEMBL9119450 | 0.81 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCCKBR | |
| SCHEMBL14193482 | 0.80 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5461048-A | Tricyclic compounds having cholecystokinin antagonist activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5401737-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |
| EP-0360079-B1 | Tricyclic compounds, processes for their preparation and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-02-02 | — | — | EP | disclosed |
| US-5248679-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| US-5155101-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-4981847-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-01 | — | — | US | disclosed |
| EP-0360079-A1 | Tricyclic compounds, processes for their preparation and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-03-28 | — | — | EP | disclosed |