Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121148 | 0.96 | CYP19A1 (0.60) | CYP19A1SLC6A3DRD4DRD3HTR2A | |
| SCHEMBL9120738 | 0.91 | CYP19A1 (0.58) | CYP19A1SLC6A3DRD4DRD3HTR2A | |
| SCHEMBL9120812 | 0.91 | CYP19A1 (0.58) | CYP19A1SLC6A3DRD4DRD3HTR2A | |
| SCHEMBL9120174 | 0.90 | SIGMAR1 (0.45) | CYP19A1HTR2ACYP3A4CYP2D6KCNH2 | |
| SCHEMBL9124186 | 0.89 | CYP19A1 (0.63) | CYP19A1SLC6A3DRD4DRD3HTR2A | |
| SCHEMBL9121781 | 0.87 | CYP19A1 (0.66) | CYP19A1SLC6A3DRD4DRD3HTR2A | |
| SCHEMBL9122640 | 0.86 | CYP19A1 (0.48) | CYP19A1MEN1ALDH1A1LMNAMAPK1 | |
| SCHEMBL9122861 | 0.85 | CYP19A1 (0.52) | CYP19A1SLC6A3KCNH2 | |
| SCHEMBL9123280 | 0.85 | CYP19A1 (0.56) | CYP19A1SLC6A3DRD4DRD3HTR2A | |
| SCHEMBL9120850 | 0.84 | CYP19A1 (0.49) | CYP19A1CHRM1MEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5439928-A | Enzyme inhibitors as antitumor agents for breast cancer | ORION-YHTYMA OY (FI) | 1995-08-08 | — | — | US | claimed |
| EP-0390558-B1 | Aromatase inhibiting 4(5)-imidazoles | ORION YHTYMAE OY (FI) | 1994-09-07 | — | — | EP | claimed |
| EP-0390558-A1 | Aromatase inhibiting 4(5)-imidazoles | ORION-YHTYMÀ OY (FI) | 1990-10-03 | — | — | EP | claimed |
| US-5439928-A | Enzyme inhibitors as antitumor agents for breast cancer | ORION-YHTYMA OY (FI) | 1995-08-08 | — | — | US | disclosed |
| EP-0390558-B1 | Aromatase inhibiting 4(5)-imidazoles | ORION YHTYMAE OY (FI) | 1994-09-07 | — | — | EP | disclosed |
| EP-0390558-A1 | Aromatase inhibiting 4(5)-imidazoles | ORION-YHTYMÀ OY (FI) | 1990-10-03 | — | — | EP | disclosed |