Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.77 |
| ▸ | DRD2 | P14416 | 5/20 | 0.77 |
| ▸ | DRD3 | P35462 | 5/20 | 0.77 |
| ▸ | HTR1A | P08908 | 5/20 | 0.77 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.77 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.77 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.77 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.77 |
| ▸ | HTR2A | P28223 | 2/20 | 0.77 |
| ▸ | HTR2B | P41595 | 2/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.77 |
| ▸ | HRH1 | P35367 | 1/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | DRD1 | P21728 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11013459 | 0.99 | ADRB2 (0.78) | ADRB2ADRA1ADRD2DRD3HTR1A | |
| Hydrochloric Acid SCHEMBL9122055 | 0.88 | ADRB2 (0.80) | ADRB2ADRA1ADRD2DRD3HTR1A | |
| SCHEMBL10956021 | 0.87 | ADRB2 (0.78) | ADRB2ADRA1ADRD2DRD3HTR1A | |
| Amosulalol SCHEMBL6509394 | 0.87 | ADRB2 (1.00) | ADRB2ADRA1ADRD2DRD3HTR1A | |
| Amosulalol SCHEMBL30136493 | 0.87 | ADRB2 (1.00) | ADRB2ADRA1ADRD2DRD3HTR1A | |
| SCHEMBL9128172 | 0.87 | ADRB2 (0.78) | ADRB2ADRA1ADRD2DRD3HTR1A | |
| Amosulalol SCHEMBL48933 | 0.87 | ADRB2 (1.00) | ADRB2ADRA1ADRD2DRD3HTR1A | |
| Amosulalol SCHEMBL50631 | 0.86 | ADRB2 (0.98) | ADRB2ADRA1ADRD2DRD3HTR1A | |
| Amosulalol SCHEMBL11020103 | 0.86 | ADRB2 (0.98) | ADRB2ADRA1ADRD2DRD3HTR1A | |
| Hydrochloric Acid SCHEMBL9124264 | 0.86 | ADRB2 (0.77) | ADRB2ADRA1ADRD2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5447958-A | Treatment of hypertension, congestive heart failure, angina pectoris, lower urinary tract dysfunction, prostatic hypertrophy | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-09-05 | — | — | US | disclosed |
| US-4868216-A | ANTIADRENERGIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-19 | — | — | US | disclosed |
| US-4731478-A | ADRENERGIC BLOCKING AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1988-03-15 | — | — | US | disclosed |
| EP-0034432-B1 | SULFAMOYL-SUBSTITUTED PHENETHYLAMINE DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS, CONTAINING THEM | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1984-04-25 | — | — | EP | disclosed |
| EP-0034432-A2 | Sulfamoyl-substituted phenethylamine derivatives, their preparation, and pharmaceutical compositions, containing them | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1981-08-26 | — | — | EP | disclosed |