Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4611607 | 0.98 | KDM4E (0.68) | KDM4EHTTSMN1; SMN2ANPEPERAP2 | |
| SCHEMBL1828528 | 0.90 | — | — | |
| SCHEMBL5930050 | 0.80 | KDM4E (0.42) | KDM4EHTTSMN1; SMN2ANPEPERAP2 | |
| SCHEMBL27980382 | 0.78 | KDM4E (1.00) | KDM4EHTTSMN1; SMN2ANPEPERAP2 | |
| SCHEMBL3393821 | 0.78 | KDM4E (0.74) | KDM4EHTTSMN1; SMN2ANPEPERAP2 | |
| SCHEMBL30777623 | 0.76 | KDM4E (0.71) | KDM4EHTTSMN1; SMN2ANPEPERAP2 | |
| SCHEMBL12423949 | 0.76 | KDM4E (0.64) | KDM4EHTTSMN1; SMN2ANPEPERAP2 | |
| SCHEMBL22260241 | 0.76 | KDM4E (0.64) | KDM4EHTTSMN1; SMN2ANPEPERAP2 | |
| SCHEMBL10778286 | 0.76 | KDM4E (0.64) | KDM4EHTTSMN1; SMN2ANPEPERAP2 | |
| SCHEMBL24715431 | 0.74 | KDM4E (0.68) | KDM4EHTTSMN1; SMN2ANPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476848-A | Antihistamines | SANKYO COMPANY, LIMITED (JP) | 1995-12-19 | — | — | US | disclosed |
| US-5461051-A | Tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use | SANKYO COMPANY, LIMITED (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5362725-A | Antiallergens, antiasthmatic | SANKYO COMPANY, LIMITED (JP) | 1994-11-08 | — | — | US | disclosed |
| EP-0505014-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1992-09-23 | — | — | EP | disclosed |
| EP-0421823-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1991-04-10 | — | — | EP | disclosed |