Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8373786 | 0.90 | ALDH1A1 (0.48) | TDP1GAAALDH1A1KMT2ACYP1A2 | |
| SCHEMBL10477945 | 0.85 | CYP1A2 (0.54) | TDP1ALDH1A1KMT2ACYP1A2MEN1 | |
| SCHEMBL9489211 | 0.85 | GAA (0.47) | TDP1GAAALDH1A1KMT2ACYP1A2 | |
| SCHEMBL10372351 | 0.84 | KMT2A (0.46) | TDP1GAAALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9558135 | 0.82 | CYP1A2 (0.53) | TDP1GAAALDH1A1KMT2ACYP1A2 | |
| SCHEMBL4078018 | 0.81 | CYP1A2 (0.56) | TDP1ALDH1A1KMT2ACYP1A2MAPT | |
| SCHEMBL9125723 | 0.77 | TSHR (0.50) | GAAALDH1A1KMT2ACYP1A2MAPT | |
| SCHEMBL1758062 | 0.77 | TDP1 (0.64) | TDP1GAAALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9840070 | 0.76 | CYP1A2 (0.40) | TDP1ALDH1A1KMT2ACYP1A2MAPT | |
| SCHEMBL3697952 | 0.75 | CYP1A2 (0.59) | TDP1ALDH1A1KMT2ACYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5413997-A | For treatment of osteoporosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-05-09 | — | — | US | disclosed |
| EP-0395093-B1 | TRIPHENYLMETHANE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |
| US-5112867-A | Osteoporosis Treatment | KYOWA HAKKO GOGYO CO., LTD. (JP) | 1992-05-12 | — | — | US | disclosed |