Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 16/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | PPIF | P30405 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2783281 | 0.90 | PPIA (0.72) | PPIAPPIF | |
| SCHEMBL9124787 | 0.90 | PPIA (0.60) | PPIARAB9ANPC1PPIFMEN1 | |
| SCHEMBL9125085 | 0.87 | PPIA (0.68) | PPIAPPIF | |
| SCHEMBL9125557 | 0.86 | PPIA (0.60) | PPIARAB9ANPC1MEN1KMT2A | |
| SCHEMBL9390383 | 0.84 | MEN1 (0.48) | RAB9ANPC1MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL9126271 | 0.83 | PPIA (0.53) | PPIARAB9ANPC1PPIF | |
| Hydrochloric Acid SCHEMBL9125189 | 0.83 | PPIA (0.53) | PPIARAB9ANPC1PPIF | |
| SCHEMBL9125073 | 0.82 | PPIA (0.75) | PPIAPPIF | |
| SCHEMBL9357577 | 0.81 | PPIA (0.60) | PPIAPPIF | |
| SCHEMBL9123645 | 0.80 | PPIA (0.52) | PPIARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |