Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | APP | P05067 | 12/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3142640 | 0.90 | MAPT (0.72) | MAPTALDH1A1RAB9AAPPTDP1 | |
| SCHEMBL7246016 | 0.89 | TDP1 (0.64) | MAPTALDH1A1RAB9AAPPTDP1 | |
| SCHEMBL13382951 | 0.87 | ALDH1A1 (0.71) | MAPTALDH1A1RAB9AAPPTDP1 | |
| SCHEMBL10920582 | 0.86 | TDP1 (0.49) | MAPTALDH1A1RAB9AAPPTDP1 | |
| SCHEMBL31123572 | 0.86 | TDP1 (0.49) | MAPTALDH1A1RAB9AAPPTDP1 | |
| SCHEMBL31123574 | 0.82 | APP (0.54) | MAPTALDH1A1RAB9AAPPTDP1 | |
| SCHEMBL7249247 | 0.82 | ALDH1A1 (0.69) | MAPTALDH1A1RAB9AAPPTDP1 | |
| SCHEMBL7913164 | 0.79 | ALDH1A1 (0.69) | MAPTALDH1A1RAB9AAPPTDP1 | |
| SCHEMBL3557966 | 0.79 | APP (0.57) | MAPTALDH1A1RAB9AAPPTDP1 | |
| SCHEMBL22049536 | 0.79 | MAOB (0.57) | MAPTALDH1A1RAB9ATDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5395610-A | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | BURROUGHS-WELLCOME CO. (US) | 1995-03-07 | — | — | US | disclosed |
| US-5300282-A | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | BURROUGHS-WELLCOME COMPANY (US) | 1994-04-05 | — | — | US | disclosed |
| EP-0409406-B1 | ARYL-SUBSTITUTED AMINE DERIVATIVES USEFUL IN CANCER THERAPY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-08 | — | — | EP | disclosed |
| EP-0487502-A2 | Pharmaceutically active aryl-substituted amine derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-05-27 | — | — | EP | disclosed |
| EP-0409406-A2 | Aryl-substituted amine derivatives useful in cancer therapy | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015599-A1 | MEDICAMENTS USEFUL IN CANCER THERAPY AND HAVING ANTIHISTAMINIC PROPERTIES | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-12-27 | — | — | WO | disclosed |