SCHEMBL9129333

SCHEMBL9129333

[O]C(OCc1ccc(Cl)cc1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.61
CHRNA4 P43681 1/20 0.61
SLC6A2 P23975 1/20 0.47
SLC6A4 P31645 1/20 0.47
SLC6A3 Q01959 1/20 0.47
PPARG P37231 2/20 0.43
PPARA Q07869 2/20 0.43
MEN1 O00255 1/20 0.42
MAPT P10636 1/20 0.42
KMT2A Q03164 1/20 0.42
IDO1 P14902 4/20 0.42
AGXT P21549 2/20 0.42
INPPL1 O15357 1/20 0.42
TDO2 P48775 2/20 0.42
CNR1 P21554 1/20 0.41
CNR2 P34972 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL790660 0.87 SLC6A2 (0.47) CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3
SCHEMBL28505841 0.81 CHRNB2 (0.65) CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3
SCHEMBL6181884 0.80 CHRNB2 (0.63) CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3
SCHEMBL2378205 0.79 ABCB1 (0.47) CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3
SCHEMBL6745046 0.78 CYP3A4 (0.50) SLC6A4IDO1AGXTCYP3A4TACR1
SCHEMBL20837528 0.78 CHRNB2 (0.56) CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3
SCHEMBL10335685 0.78 PPARG (0.45) CHRNB2CHRNA4PPARGMEN1MAPT
SCHEMBL10700140 0.77 CHRNB2 (0.55) CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3
SCHEMBL19156028 0.76 CHRNB2 (0.91) CHRNB2CHRNA4SLC6A2SLC6A4SLC6A3
SCHEMBL11227027 0.74 PPARA (0.57) CHRNB2CHRNA4PPARGPPARAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5418230-A Antiinflammatory SHIONOGI & CO., LTD. (JP) 1995-05-23 US disclosed