⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9129590 | 1.00 | — | — | |
| SCHEMBL9128025 | 0.96 | — | — | |
| SCHEMBL9129879 | 0.96 | — | — | |
| SCHEMBL9130655 | 0.96 | — | — | |
| SCHEMBL9130498 | 0.91 | FDPS (0.44) | — | |
| SCHEMBL9127713 | 0.86 | FNTA (0.50) | — | |
| SCHEMBL9632034 | 0.85 | — | — | |
| SCHEMBL9633372 | 0.85 | — | — | |
| SCHEMBL9633364 | 0.85 | — | — | |
| SCHEMBL9632023 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428028-A | Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0514124-A2 | Use of phosphonomethylphosphinate squalene synthetase inhibitors for the manufacture of a medicament for the lowering cholesterol | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |