Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 10/20 | 0.48 |
| ▸ | FES | P07332 | 1/20 | 0.48 |
| ▸ | FER | P16591 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912959 | 1.00 | PIKFYVE (0.48) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL12903017 | 0.88 | PIKFYVE (0.63) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL913585 | 0.87 | PIKFYVE (0.51) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL913583 | 0.87 | PIKFYVE (0.51) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL912404 | 0.84 | PIKFYVE (0.54) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL912405 | 0.84 | PIKFYVE (0.54) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL913150 | 0.83 | PIKFYVE (0.53) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL913152 | 0.83 | PIKFYVE (0.53) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL12903016 | 0.75 | PIKFYVE (0.68) | PIKFYVEFESFERTYK2FRK | |
| SCHEMBL427744 | 0.74 | PIKFYVE (0.51) | PIKFYVEFESFERTYK2FRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872005-B2 | 2-substituted heteroaryl compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-01-18 | — | — | US | claimed |
| US-20060063739-A1 | 2-Substituted heteroaryl compounds | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2006-03-23 | — | — | US | claimed |
| US-7872005-B2 | 2-substituted heteroaryl compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-01-18 | — | — | US | disclosed |
| US-20060063739-A1 | 2-Substituted heteroaryl compounds | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063739-A1 | 2-Substituted heteroaryl compounds | IL2, IL4, IL2RA | PIKFYVE 4258/4885FES 2427/4885FER 3322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.