Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 5/20 | 0.96 |
| ▸ | FNTB | P49356 | 5/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625937 | 1.00 | FNTA (0.96) | FNTAFNTBKDM4EATMKMT2A | |
| SCHEMBL8625931 | 1.00 | FNTA (0.96) | FNTAFNTBKDM4EATMKMT2A | |
| SCHEMBL16792146 | 0.98 | FNTA (1.00) | FNTAFNTBKDM4EATMKMT2A | |
| SCHEMBL11703920 | 0.98 | FNTA (1.00) | FNTAFNTBKDM4EATMKMT2A | |
| SCHEMBL3271383 | 0.92 | FNTA (0.83) | FNTAFNTBKDM4EATMKMT2A | |
| SCHEMBL17223965 | 0.91 | FNTA (0.86) | FNTAFNTBKDM4EATMKMT2A | |
| SCHEMBL17223966 | 0.91 | FNTA (0.86) | FNTAFNTBKDM4EATMKMT2A | |
| SCHEMBL14815638 | 0.88 | FNTA (0.76) | FNTAFNTBKDM4EATMKMT2A | |
| SCHEMBL9474585 | 0.88 | FNTA (0.75) | FNTAFNTBKDM4EATMKMT2A | |
| SCHEMBL9474569 | 0.88 | FNTA (0.75) | FNTAFNTBKDM4EATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428028-A | Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0514124-A2 | Use of phosphonomethylphosphinate squalene synthetase inhibitors for the manufacture of a medicament for the lowering cholesterol | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |