SCHEMBL9129781

SCHEMBL9129781

O=C(O)c1ccc(Oc2ccc(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)c3ccc(Oc4ccc(C(=O)O)c(C(=O)O)c4)cc3)cc2)cc1C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.54
HPSE Q9Y251 1/20 0.47
ALDH1A1 P00352 3/20 0.45
L3MBTL1 Q9Y468 2/20 0.43
APEX1 P27695 1/20 0.43
CTDSP1 Q9GZU7 1/20 0.43
TDP1 Q9NUW8 5/20 0.43
LMNA P02545 1/20 0.43
GALK1 P51570 1/20 0.42
CASP6 P55212 1/20 0.42
MCL1 Q07820 1/20 0.42
PLEC Q15149 1/20 0.42
PYGL P06737 3/20 0.41
PYGM P11217 2/20 0.41
DUSP3 P51452 1/20 0.41
PTPN5 P54829 1/20 0.41
PTPN11 Q06124 1/20 0.41
KDM4E B2RXH2 2/20 0.41
HPGD P15428 2/20 0.41
HSD17B10 Q99714 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9131653 1.00 POLB (0.54) POLBHPSEALDH1A1L3MBTL1APEX1
SCHEMBL10625500 1.00 POLB (0.54) POLBHPSEALDH1A1L3MBTL1APEX1
SCHEMBL9128762 0.95 POLB (0.55) POLBHPSEALDH1A1L3MBTL1APEX1
SCHEMBL523943 0.86 POLB (0.58) POLBHPSEALDH1A1L3MBTL1APEX1
SCHEMBL4890609 0.85 POLB (0.51) POLBHPSEALDH1A1L3MBTL1APEX1
SCHEMBL9460665 0.85 POLB (0.51) POLBHPSEALDH1A1L3MBTL1APEX1
SCHEMBL11338178 0.84 POLB (0.52) POLBHPSEALDH1A1L3MBTL1APEX1
SCHEMBL31525219 0.84 POLB (0.52) POLBHPSEALDH1A1L3MBTL1APEX1
SCHEMBL8923122 0.84 POLB (0.52) POLBHPSEALDH1A1L3MBTL1APEX1
SCHEMBL29405914 0.83 POLB (0.55) POLBHPSEALDH1A1L3MBTL1APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0400635-B1 Liquid crystal device CANON KK (JP) 1995-09-27 EP claimed
US-5192596-A Polyimide CANON KABUSHIKI KAISHA (JP) 1993-03-09 US claimed
EP-0400635-A2 Liquid crystal device CANON KABUSHIKI KAISHA (JP) 1990-12-05 EP claimed
EP-0400635-B1 Liquid crystal device CANON KK (JP) 1995-09-27 EP disclosed
US-5426525-A Ferroelectric smectic liquid crystal device CANON KABUSHIKI KAISHA (JP) 1995-06-20 US disclosed
EP-0373952-B1 Photosensitive resin composition and photosensitive element using the same HITACHI CHEMICAL CO LTD (JP) 1995-02-08 EP disclosed
US-5316805-A Liquid crystal device CANON KABUSHIKI KAISHA (JP) 1994-05-31 US disclosed
US-5262277-A Light sensitive elements for electrical thick films with heat resistance HITACHI CHEMICAL COMPANY, INC. (JP) 1993-11-16 US disclosed
EP-0219336-B1 LIQUID CRYSTAL ORIENTATION CONTROLLING FILM AND LIQUID CRYSTAL DEVICE USING THE SAME Hitachi Chemical Co., Ltd. (JP) 1993-07-21 EP disclosed
US-5192596-A Polyimide CANON KABUSHIKI KAISHA (JP) 1993-03-09 US disclosed
EP-0400635-A2 Liquid crystal device CANON KABUSHIKI KAISHA (JP) 1990-12-05 EP disclosed
EP-0373952-A2 Photosensitive resin composition and photosensitive element using the same Hitachi Chemical Co., Ltd. (JP) 1990-06-20 EP disclosed
US-4760126-A Fluorine-containing polyamide-acid derivative and polyimide HITACHI, LTD. (JP) 1988-07-26 US disclosed
US-4735492-A POLYIMIDE-ISOIDOLOQUINAZOLINEDIONE HITACHI CHEMICAL COMPANY, LTD. (JP) 1988-04-05 US disclosed
EP-0219336-A2 Liquid crystal orientation controlling film and liquid crystal device using the same Hitachi Chemical Co., Ltd. (JP) 1987-04-22 EP disclosed
EP-0142149-A2 Use of fluorine containing polyimides for aligning layers of liquid crystal display devices. HITACHI, LTD. (JP) 1985-05-22 EP disclosed