Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 8/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132364 | 0.85 | FEN1 (0.50) | FEN1ALDH1A1TSHRCYP2C19PDE4A | |
| SCHEMBL9131517 | 0.82 | FEN1 (0.45) | FEN1ALDH1A1TSHRCYP2C19PDE4A | |
| SCHEMBL9132830 | 0.78 | FEN1 (0.46) | FEN1ALDH1A1TSHRCYP2C19PDE4A | |
| SCHEMBL9131042 | 0.76 | PTGDR2 (0.46) | FEN1ALDH1A1TSHRCYP2C19PDE4A | |
| SCHEMBL10377175 | 0.74 | FEN1 (0.47) | FEN1ALDH1A1TSHRCYP2C19PDE4A | |
| SCHEMBL9352322 | 0.74 | FEN1 (0.47) | FEN1ALDH1A1TSHRCYP2C19PDE4A | |
| SCHEMBL9726994 | 0.73 | PDE4A (0.47) | FEN1ALDH1A1TSHRCYP2C19PDE4A | |
| SCHEMBL10841285 | 0.72 | FEN1 (0.45) | FEN1ALDH1A1TSHRCYP2C19PDE4A | |
| SCHEMBL30438257 | 0.72 | MAPT (0.49) | FEN1ALDH1A1TSHRCYP2C19PDE4A | |
| SCHEMBL6009928 | 0.72 | MAPT (0.49) | FEN1ALDH1A1TSHRCYP2C19PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5439916-A | Antiallergens,-inflammatory and -ulcer agents; hypotensive agents; immunosuppressants; skin disorders | SCHERING CORPORATION (US) | 1995-08-08 | — | — | US | disclosed |
| US-5126352-A | Antiallergy, antiinflammatory, antiulcer, hypotensive, antibody inhibitors | SCHERING CORPORATION (US) | 1992-06-30 | — | — | US | disclosed |
| US-5116840-A | Antiulcer, antiinflammatory, hypotensive, immunosuppressants | SCHERING CORPORATION (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0229823-B1 | POLYCYCLIC QUINOLINE, NAPHTHYRIDINE AND PYRAZINOPYRIDINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-09-25 | — | — | EP | disclosed |
| US-4988705-A | Antiallergens and -inflammatory agents; hypotensive agents immunological suppression; hyperproliferative skin disorders such as psoriasis | SCHERING CORPORATION (US) | 1991-01-29 | — | — | US | disclosed |
| US-4810708-A | ANTIALLERGY, IMMUNOSUPPRESSIVE | SCHERING CORPORATION (US) | 1989-03-07 | — | — | US | disclosed |