Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4136705 | 0.84 | PRMT5 (0.52) | PRMT5WDR77GPR119USP30PIK3CD | |
| SCHEMBL31071544 | 0.84 | KEAP1 (0.52) | PRMT5WDR77GPR119USP30KDM4E | |
| SCHEMBL4136707 | 0.84 | PRMT5 (0.52) | PRMT5WDR77GPR119USP30PIK3CD | |
| SCHEMBL26612365 | 0.83 | TTR (0.53) | PRMT5WDR77GPR119USP30KDM4E | |
| SCHEMBL697850 | 0.82 | JAK2 (0.55) | PRMT5WDR77GPR119USP30KDM4E | |
| SCHEMBL20503925 | 0.82 | JAK2 (0.55) | PRMT5WDR77GPR119USP30KDM4E | |
| SCHEMBL942191 | 0.82 | JAK2 (0.55) | PRMT5WDR77GPR119USP30KDM4E | |
| SCHEMBL14202662 | 0.81 | PIK3CD (0.51) | PRMT5WDR77GPR119USP30PIK3CD | |
| SCHEMBL16112711 | 0.81 | KDM4E (0.58) | ACHEGPR119KDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL14204244 | 0.80 | PRMT5 (0.50) | PRMT5WDR77GPR119USP30KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5453437-A | 1,3-disubstituted pyrrolidines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-09-26 | — | — | US | disclosed |
| US-5274097-A | A 1-N-heterocyclic alkylene-3-carbo or heterocyclic ring oxypyrrolidine derivative | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| EP-0338331-B1 | 1,3 DISUBSTITUTED PYRROLIDINES | BAYER AG (DE) | 1992-10-21 | — | — | EP | disclosed |
| US-5037841-A | For treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |
| EP-0338331-A1 | 1,3 Disubstituted Pyrrolidines | BAYER AG (DE) | 1989-10-25 | — | — | EP | disclosed |