Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.68 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9073927 | 0.94 | APP (0.68) | APPVCPMAPTALDH1A1HPGD | |
| SCHEMBL9131883 | 0.84 | APP (0.59) | APPVCPMAPTALDH1A1HPGD | |
| SCHEMBL9132523 | 0.84 | APP (0.49) | APPVCPMAPTALDH1A1GFER | |
| SCHEMBL9184573 | 0.80 | APP (0.51) | APPMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL28972857 | 0.79 | APP (0.69) | APPVCPMAPTALDH1A1HPGD | |
| SCHEMBL9069649 | 0.78 | VCP (0.59) | APPVCPMAPTALDH1A1HPGD | |
| SCHEMBL9131641 | 0.78 | APP (0.56) | APPVCPMAPTALDH1A1HPGD | |
| SCHEMBL9804473 | 0.77 | CHRM5 (0.62) | APPMAPTALDH1A1CHRM5CHKA | |
| SCHEMBL9131344 | 0.77 | APP (0.62) | APPVCPMAPTALDH1A1HPGD | |
| SCHEMBL9131411 | 0.76 | APP (0.61) | APPVCPMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476658-B1 | 1-Phenyl-3-phenyl-2-propyne-1-ones | MERRELL DOW PHARMA (US) | 1995-11-15 | — | — | EP | claimed |
| EP-0476645-B1 | Calcium uptake inhibitors | MERRELL DOW PHARMA (US) | 1995-09-06 | — | — | EP | claimed |
| US-5223518-A | Controlling intake in leukocytes and platelets | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-29 | — | — | US | claimed |
| EP-0476645-A1 | Calcium uptake inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-25 | — | — | EP | claimed |
| EP-0476658-B1 | 1-Phenyl-3-phenyl-2-propyne-1-ones | MERRELL DOW PHARMA (US) | 1995-11-15 | — | — | EP | disclosed |
| EP-0476645-B1 | Calcium uptake inhibitors | MERRELL DOW PHARMA (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5446068-A | Antiinflammatory agent | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5409942-A | Administering 1-phenyl-3-aryl-2-propyne-1-ones compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5248825-A | Aromatic ketones containing triple bond | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-28 | — | — | US | disclosed |
| US-5223518-A | Controlling intake in leukocytes and platelets | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-29 | — | — | US | disclosed |
| EP-0476645-A1 | Calcium uptake inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| EP-0476658-A1 | 1-Phenyl-3-phenyl-2-propyne-1-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-25 | — | — | EP | disclosed |