Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | SLC33A1 | O00400 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679819 | 0.95 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL7683433 | 0.94 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL7677786 | 0.94 | SLC33A1 (0.37) | AGTR1AGTR2SLC33A1 | |
| SCHEMBL7679692 | 0.93 | SLC33A1 (0.34) | AGTR1AGTR2ADORA1SLC33A1 | |
| SCHEMBL7681728 | 0.92 | AGTR1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL7677700 | 0.91 | AGTR1 (0.36) | AGTR1AGTR2ADORA2AADORA2BADORA1 | |
| SCHEMBL7686080 | 0.91 | AGTR1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL7679563 | 0.91 | SLC33A1 (0.34) | AGTR1AGTR2SLC33A1 | |
| SCHEMBL9036014 | 0.90 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL7686858 | 0.89 | SLC33A1 (0.32) | AGTR1AGTR2SLC33A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5441970-A | Administering angiotensin II antagonists to treat congestive heart failure or hypertension | G. D. SEARLE & CO. (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0579766-A1 | N-ARYLHETEROARYLALKYL IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1994-01-26 | — | — | EP | disclosed |
| US-5164403-A | Hypotensive agents, cardiovascular disorders | G. D. SEARLE & CO. (US) | 1992-11-17 | — | — | US | disclosed |
| WO-1992017469-A2 | N-ARYLHETEROARYLALKYL IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-10-15 | — | — | WO | disclosed |
| EP-0508393-A1 | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders | G.D. Searle & Co. (US) | 1992-10-14 | — | — | EP | disclosed |