Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23028112 | 0.90 | TRPV1 (0.48) | CYP1A2TRPV1PDGFRBPDGFRALMNA | |
| SCHEMBL1253866 | 0.76 | CYP1A2 (0.59) | CYP1A2PDGFRBPDGFRARAB9AALDH1A1 | |
| SCHEMBL13749462 | 0.74 | TRPV1 (0.45) | CYP1A2TRPV1PDGFRBPDGFRALMNA | |
| Hydrochloric Acid SCHEMBL8326092 | 0.74 | CYP1A2 (0.57) | CYP1A2PDGFRBPDGFRARAB9AALDH1A1 | |
| SCHEMBL27941834 | 0.74 | INSR (0.47) | CYP1A2RAB9AMAPTKDM4E | |
| SCHEMBL16483982 | 0.74 | CYP1A2 (0.52) | CYP1A2PDGFRBPDGFRALMNAPOLB | |
| SCHEMBL12890436 | 0.74 | CYP1A2 (0.52) | CYP1A2PDGFRBPDGFRARAB9ATLR8 | |
| SCHEMBL14582925 | 0.74 | PDE10A (0.44) | LMNARAB9AALDH1A1MAPTHPGD | |
| SCHEMBL14680365 | 0.74 | CYP1A2 (0.55) | CYP1A2PDGFRBPDGFRALMNAPOLB | |
| SCHEMBL9288445 | 0.73 | MAPT (0.40) | CYP1A2TRPV1TLR8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |