Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | CNR2 | P34972 | 2/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.53 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28409458 | 0.90 | EGFR (0.65) | HDAC1HDAC6HDAC3HDAC2CNR2 | |
| SCHEMBL3113511 | 0.88 | GAA (0.52) | HDAC1HDAC6HDAC3HDAC2CNR2 | |
| SCHEMBL6674114 | 0.81 | EGFR (0.70) | HDAC1HDAC6HDAC3HDAC2CNR2 | |
| SCHEMBL28884103 | 0.81 | HDAC1 (0.74) | HDAC1HDAC6HDAC3HDAC2LTB4R2 | |
| SCHEMBL20679865 | 0.81 | EGFR (0.66) | HDAC1HDAC6HDAC3HDAC2CNR2 | |
| SCHEMBL11224660 | 0.81 | EGFR (0.55) | HDAC1HDAC6HDAC3HDAC2CNR2 | |
| SCHEMBL9356480 | 0.79 | EGFR (0.51) | HDAC1HDAC3HDAC2TSHREGFR | |
| SCHEMBL11320468 | 0.78 | AGER (0.50) | HDAC1HDAC6HDAC3HDAC2LIMK1 | |
| SCHEMBL11326249 | 0.77 | LPAR1 (0.54) | HDAC1HDAC6TSHRHPGD | |
| SCHEMBL95412 | 0.77 | HDAC1 (0.52) | HDAC1HDAC6CNR2HSP90AA1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5422355-A | Also for treating memory impairment, dementia or cerebral insufficiency | JOHN WYETH & BROTHER, LIMITED (GB) | 1995-06-06 | — | — | US | disclosed |
| EP-0407032-B1 | Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia | WYETH JOHN & BROTHER LTD (GB) | 1994-11-09 | — | — | EP | disclosed |
| US-5260331-A | Selective gamma aminobutyric acid autoreceptors; treatment of dementia | JOHN WYETH & BROTHER LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| US-5086073-A | Brain disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1992-02-04 | — | — | US | disclosed |
| EP-0407032-A2 | Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia | JOHN WYETH & BROTHER LIMITED (GB) | 1991-01-09 | — | — | EP | disclosed |