Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | CASP1 | P29466 | 4/20 | 0.61 |
| ▸ | CASP7 | P55210 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38663343 | 0.87 | ALDH1A1 (0.83) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL9669237 | 0.86 | MEN1 (0.68) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL10334432 | 0.79 | MAPT (0.65) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL8638914 | 0.78 | PTPN1 (0.58) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL1627835 | 0.78 | ALDH1A1 (1.00) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL7527991 | 0.78 | ALDH1A1 (0.54) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL5196128 | 0.77 | HSD17B3 (0.67) | ALDH1A1CYP2C9TSHRKDM4EHSD17B10 | |
| SCHEMBL25327302 | 0.77 | MAPT (0.72) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL30523094 | 0.77 | MAPT (0.72) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL5088627 | 0.77 | ERAP1 (0.83) | ALDH1A1CYP3A4TSHRTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021669-A1 | 2-PHENYLBENZO[B]FURANS AND THIOPHENES, METHODS OF PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-10 | — | — | WO | claimed |
| EP-0516257-A1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-02 | — | — | EP | claimed |
| US-5470854-A | Antiestrogens | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-11-28 | — | — | US | disclosed |
| WO-1992021669-A1 | 2-PHENYLBENZO[B]FURANS AND THIOPHENES, METHODS OF PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-10 | — | — | WO | disclosed |
| EP-0516257-A1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-02 | — | — | EP | disclosed |