Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 7/20 | 1.00 |
| ▸ | FADS1 | O60427 | 1/20 | 0.79 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914427 | 0.88 | SCD (1.00) | SCDFADS1 | |
| SCHEMBL914248 | 0.85 | SCD (0.78) | SCDFADS1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12942716 | 0.85 | SCD (0.74) | SCDFADS1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15640487 | 0.85 | CHEK2 (0.79) | SCDCHEK2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29545711 | 0.82 | SCD (0.69) | SCDFADS1CHEK2CYP1A2CYP3A4 | |
| SCHEMBL913411 | 0.79 | SCD (0.67) | SCDFADS1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL914190 | 0.79 | SCD (0.67) | SCDFADS1HDAC6 | |
| SCHEMBL6684135 | 0.77 | CHEK2 (1.00) | SCDCHEK2HDAC6 | |
| SCHEMBL913038 | 0.76 | SCD (0.65) | SCDFADS1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL913107 | 0.76 | SCD (0.75) | SCDFADS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279177-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | Merck Frosst Canada Ltd. (CA) | 2011-02-02 | — | — | EP | disclosed |
| US-20110021532-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. | 2011-01-27 | — | — | US | disclosed |
| US-20110021532-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. | 2011-01-27 | — | — | US | disclosed |
| WO-2009129625-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009129625-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021532-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | SCD, SCD5, FASN | SCD 1/4885FADS1 9/4885CHEK2 3427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.