Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9135228 | 0.85 | POLB (0.54) | KDM4EALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL8597367 | 0.81 | CA12 (0.51) | KDM4EALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL11233586 | 0.78 | CA1 (0.68) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL9139438 | 0.77 | TNKS (0.46) | KDM4EALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL9455121 | 0.75 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL16351874 | 0.75 | CA1 (0.73) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL1965326 | 0.75 | CA1 (0.73) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL3189642 | 0.74 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL25911102 | 0.73 | KDM4E (0.80) | KDM4EALDH1A1HPGDPOLBMAPK1 | |
| SCHEMBL87450 | 0.73 | CA1 (0.83) | ALDH1A1HPGDCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380730-A | Angiotensin antagonist | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-01-10 | — | — | US | disclosed |
| US-5236936-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0499416-A2 | Pyridine compounds as angiotensin II antagonists, processes for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |