Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.63 |
| ▸ | HTR1D | P28221 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | HTR1B | P28222 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13962815 | 0.84 | SLC6A4 (0.66) | HTR2AHTR1DMAPTMTNR1AMTNR1B | |
| SCHEMBL13962824 | 0.84 | SLC6A4 (0.66) | HTR2AHTR1DMAPTMTNR1AMTNR1B | |
| SCHEMBL1520131 | 0.81 | HTR2A (0.82) | HTR2AHTR1DMAPTMEN1LMNA | |
| SCHEMBL27929459 | 0.81 | HTR2A (0.67) | HTR2AHTR1DMAPTMEN1LMNA | |
| SCHEMBL78477 | 0.81 | HTR1D (0.66) | HTR2AHTR1DMAPTHTR1AHTR1B | |
| SCHEMBL31215137 | 0.80 | HTR1D (0.65) | HTR2AHTR1DMAPTMEN1LMNA | |
| SCHEMBL8243669 | 0.80 | SLC6A4 (0.62) | HTR2AHTR1DMAPTMEN1LMNA | |
| SCHEMBL8344495 | 0.79 | HTR1D (0.73) | HTR2AHTR1DMAPTMEN1LMNA | |
| SCHEMBL18932886 | 0.78 | HTR2A (0.71) | HTR2AHTR1DMAPTMEN1LMNA | |
| SCHEMBL2831695 | 0.78 | HTR2A (0.71) | HTR2AHTR1DMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| EP-1717226-B1 | 2,7-SUBSTITUTED 5-AMINO-4-HYDROXY-8-(1H-INDOL-5-YL)-OCTAN AMIDE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | SPEEDEL EXPERIMENTA AG (CH) | 2009-01-21 | — | — | EP | disclosed |