Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 19/20 | 1.00 |
| ▸ | PTAFR | P25105 | 1/20 | 0.77 |
| ▸ | FNTA | P49354 | 1/20 | 0.72 |
| ▸ | FNTB | P49356 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16385871 | 0.92 | HRH1 (0.87) | HRH1PTAFRFNTAFNTBKCNH2 | |
| SCHEMBL9142787 | 0.91 | HRH1 (1.00) | HRH1PTAFRFNTAFNTBKCNH2 | |
| SCHEMBL9140352 | 0.89 | HRH1 (0.85) | HRH1PTAFRKCNH2 | |
| SCHEMBL31169376 | 0.88 | HRH1 (0.80) | HRH1PTAFRKCNH2 | |
| SCHEMBL20952211 | 0.88 | HRH1 (0.80) | HRH1PTAFRKCNH2 | |
| SCHEMBL25441281 | 0.88 | HRH1 (0.80) | HRH1PTAFRKCNH2 | |
| SCHEMBL9755021 | 0.88 | HRH1 (0.78) | HRH1PTAFRFNTAFNTBKCNH2 | |
| Rupatadine SCHEMBL29400290 | 0.87 | HRH1 (1.00) | HRH1PTAFRFNTAFNTBKCNH2 | |
| SCHEMBL9138981 | 0.87 | HRH1 (0.80) | HRH1PTAFRFNTAFNTBKCNH2 | |
| Rupatadine SCHEMBL30730975 | 0.87 | HRH1 (1.00) | HRH1PTAFRFNTAFNTBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476856-A | Treatment of PAF and histamine-mediated diseases with 8-chloro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | J. URIACH & CIA. S.A. (ES) | 1995-12-19 | — | — | US | disclosed |
| EP-0535152-B1 | Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylene and piperazine compounds as PAF antagonists and compositions thereof. | SCHERING CORP (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5422351-A | Antiallergens; antiinflammatory agents | SCHERING CORPORATION (US) | 1995-06-06 | — | — | US | disclosed |
| US-5407941-A | Platelet activating factor antagonist and antihistamine; useful for treating asthma and allergic disorders | J. URIACH & CIA. S.A. (ES) | 1995-04-18 | — | — | US | disclosed |