Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL20740773 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL11334598 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL8546116 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL29286967 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL27702283 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL11643635 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL28458023 | 0.92 | MEN1 (0.46) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL9137020 | 0.88 | MEN1 (0.43) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL11287089 | 0.87 | MEN1 (0.50) | MEN1KMT2ACA5ACA5BCA1 | |
| Bicarbonate SCHEMBL6804513 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5435821-A | Mixture of fertilizer, enzyme inhibitor, release film of sulfonated polymer for controlled release | EXXON RESEARCH & ENGINEERING CO. (US) | 1995-07-25 | — | — | US | claimed |
| EP-0664774-A1 | IMPROVED COATINGS WITH IONICALLY AND COVALENTLY CROSSLINKED NEUTRALIZED CARBOXYLATED POLYMERS | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1995-08-02 | — | — | EP | disclosed |
| US-5435821-A | Mixture of fertilizer, enzyme inhibitor, release film of sulfonated polymer for controlled release | EXXON RESEARCH & ENGINEERING CO. (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0664774-A4 | IMPROVED COATINGS WITH IONICALLY AND COVALENTLY CROSSLINKED NEUTRALIZED CARBOXYLATED POLYMERS. | EXXON RESEARCH ENGINEERING CO (US) | 1994-07-27 | — | — | EP | disclosed |
| US-5256181-A | Encapsulation of fertilizers | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0357687-B1 | SULFONATED POLYMER COATINGS FOR CONTROLLED FERTILIZER RELEASE | EXXON CHEMICAL PATENTS INC. (US) | 1993-05-12 | — | — | EP | disclosed |
| US-5188654-A | Fertilizer coated with thin film for controlled release and barriers to water soluble constituents | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1993-02-23 | — | — | US | disclosed |
| WO-1992017424-A1 | IMPROVED COATINGS WITH IONICALLY AND COVALENTLY CROSSLINKED NEUTRALIZED CARBOXYLATED POLYMERS | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1992-10-15 | — | — | WO | disclosed |
| CN-1044025-A | With sulfonated polymer film plant growth promoter, production method and the using method of sustained release | EXXON CHEMICAL PATENTS INC (US) | 1990-07-25 | — | — | CN | disclosed |
| EP-0357687-A1 | SULFONATED POLYMER COATINGS FOR CONTROLLED FERTILIZER RELEASE | EXXON CHEMICAL PATENTS INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| CN-1035033-A | Plant promoting agent and the production and the use of the sustained release that sulfonated high polymer applies | EXXON CHEMICAL PATENTS INC (US) | 1989-08-30 | — | — | CN | disclosed |
| WO-1989003811-A1 | SULFONATED POLYMER COATINGS FOR CONTROLLED FERTILIZER RELEASE | EXXON CHEMICAL PATENTS, INC. (US) | 1989-05-05 | — | — | WO | disclosed |