SCHEMBL9137477

SCHEMBL9137477

Cc1cc(NC(=S)NC(=O)c2c(F)cccc2F)c(C)c(Cl)c1Oc1ccc(N(C)C)c2ccccc12

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.37
KMT2A Q03164 9/20 0.37
MAPT P10636 8/20 0.37
MEN1 O00255 7/20 0.37
LMNA P02545 2/20 0.37
KDM4E B2RXH2 6/20 0.37
HPGD P15428 1/20 0.37
RAB9A P51151 3/20 0.35
NPC1 O15118 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
HTT P42858 1/20 0.35
POLB P06746 2/20 0.35
ALOX12 P18054 3/20 0.34
TDP1 Q9NUW8 1/20 0.34
GAA P10253 2/20 0.33
USP2 O75604 1/20 0.33
ALOX15 P16050 1/20 0.33
RECQL P46063 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8662761 0.90 ESRRA (0.41) ALDH1A1KMT2AMAPTMEN1LMNA
SCHEMBL9137542 0.88 ALDH1A1 (0.36) ALDH1A1KMT2AMAPTMEN1LMNA
SCHEMBL8657635 0.84 ESRRA (0.41) ALDH1A1KMT2AMAPTMEN1LMNA
SCHEMBL9133955 0.84 ESRRA (0.39) ALDH1A1KMT2AMAPTMEN1LMNA
SCHEMBL8660879 0.83 ESRRA (0.41) ALDH1A1KMT2AMAPTMEN1LMNA
SCHEMBL8659364 0.83 KMT2A (0.39) ALDH1A1KMT2AMAPTMEN1LMNA
SCHEMBL8657862 0.82 ALDH1A1 (0.39) ALDH1A1KMT2AMAPTMEN1LMNA
SCHEMBL8662507 0.81 MAPT (0.48) ALDH1A1KMT2AMAPTMEN1LMNA
SCHEMBL8657601 0.81 KMT2A (0.49) KMT2AMAPTMEN1KDM4ERAB9A
SCHEMBL8661083 0.80 ALDH1A1 (0.40) ALDH1A1KMT2AMAPTMEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed