Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terfenadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | HTR2B | P41595 | 3/20 | 0.59 |
| ▸ | BLM | P54132 | 3/20 | 0.59 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | DRD1 | P21728 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terfenadine SCHEMBL3752491 | 0.94 | LMNA (0.66) | KCNH2LMNAHRH1HTR2ADRD3 | |
| SCHEMBL18590353 | 0.79 | KCNH2 (0.78) | KCNH2LMNAHRH1HTR2ADRD3 | |
| SCHEMBL9076669 | 0.79 | KCNH2 (0.78) | KCNH2LMNAHRH1HTR2ADRD3 | |
| Terfenadine SCHEMBL27965234 | 0.78 | KCNH2 (0.98) | KCNH2LMNAHRH1HTR2ADRD3 | |
| R-Terfenadine SCHEMBL155924 | 0.77 | KCNH2 (1.00) | KCNH2LMNAHRH1HTR2ADRD3 | |
| Terfenadine SCHEMBL5152 | 0.77 | KCNH2 (1.00) | KCNH2LMNAHRH1HTR2ADRD3 | |
| Terfenadine SCHEMBL5998456 | 0.77 | KCNH2 (1.00) | KCNH2LMNAHRH1HTR2ADRD3 | |
| Terfenadine SCHEMBL5999023 | 0.77 | KCNH2 (1.00) | KCNH2LMNAHRH1HTR2ADRD3 | |
| Terfenadine SCHEMBL5999024 | 0.77 | KCNH2 (1.00) | KCNH2LMNAHRH1HTR2ADRD3 | |
| SCHEMBL11857869 | 0.77 | KCNH2 (1.00) | KCNH2LMNAHRH1HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5461059-A | Antihistamine; treats allergies and asthma | LABORATOIRE THERAMEX S.A. (FR) | 1995-10-24 | — | — | US | disclosed |