Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2865249 | 0.94 | HCAR2 (0.56) | HCAR2HCAR3NPC1RAB9AMAPT | |
| SCHEMBL8512535 | 0.92 | HCAR2 (0.57) | HCAR2HCAR3NPC1RAB9AMAPT | |
| SCHEMBL1706467 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL1707357 | 0.86 | NPC1 (0.54) | HCAR2HCAR3NPC1RAB9AMAPT | |
| SCHEMBL4011081 | 0.82 | GAA (0.42) | HCAR2HCAR3NPC1RAB9AMAPT | |
| SCHEMBL4161900 | 0.79 | HCAR2 (0.45) | HCAR2HCAR3NPC1RAB9AMAPT | |
| SCHEMBL174227 | 0.79 | — | — | |
| SCHEMBL27396391 | 0.78 | DAO (0.41) | HCAR2HCAR3NPC1RAB9AMAPT | |
| SCHEMBL23891666 | 0.78 | HCAR2 (0.56) | HCAR2HCAR3NPC1RAB9ANOS2 | |
| SCHEMBL2765959 | 0.78 | HCAR2 (0.56) | HCAR2HCAR3NOS2HRH3DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5475114-A | Angiotensin-11 antagonist; therapeutical agent used for treating hypertension and chronic heart failure | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-12-12 | — | — | US | disclosed |
| EP-0646584-A1 | PYRAZOLOTRIAZOLE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1995-04-05 | — | — | EP | disclosed |
| CN-1069978-A | Pyrazolotriazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1993-03-17 | — | — | CN | disclosed |