Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.74 |
| ▸ | MTOR | P42345 | 2/20 | 0.74 |
| ▸ | THRB | P10828 | 1/20 | 0.74 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.74 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.74 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.53 |
| ▸ | ALB | P02768 | 2/20 | 0.53 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.53 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.53 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886847 | 0.92 | LMNA (0.70) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL6758928 | 0.91 | LMNA (0.81) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL22941495 | 0.91 | LMNA (0.81) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL10431780 | 0.91 | LMNA (0.81) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL8888560 | 0.91 | LMNA (0.69) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL9945543 | 0.91 | LMNA (0.81) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL6758931 | 0.91 | LMNA (0.81) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL6758933 | 0.91 | LMNA (0.81) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL8889230 | 0.91 | LMNA (0.69) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL8887676 | 0.91 | LMNA (0.69) | LMNAMTORTHRBMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420276-A | Ring contraction via diazoketone intermediate, active against herpes | ABBOTT LABORATORIES (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0433898-A2 | Analogs of oxetanyl purines and pyrimidines | ABBOTT LABORATORIES (US) | 1991-06-26 | — | — | EP | disclosed |