Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9151183 | 0.86 | ALDH1A1 (0.47) | CYP3A4ALDH1A1TSHRHPGDHSD17B10 | |
| SCHEMBL9147302 | 0.85 | POLB (0.44) | CYP3A4ALDH1A1TSHRHPGDHSD17B10 | |
| SCHEMBL9148307 | 0.84 | NPSR1 (0.48) | CYP3A4ALDH1A1TSHRHPGDNPSR1 | |
| SCHEMBL9148810 | 0.83 | MEN1 (0.48) | CYP3A4ALDH1A1TSHRHPGDNPSR1 | |
| SCHEMBL9150813 | 0.82 | CYP3A4 (0.56) | CYP3A4ALDH1A1TSHRHPGDHSD17B10 | |
| SCHEMBL12682436 | 0.81 | CYP3A4 (0.69) | CYP3A4ALDH1A1TSHRHPGDHSD17B10 | |
| Propionic Acid SCHEMBL28762646 | 0.78 | HPGD (0.40) | CYP3A4ALDH1A1TSHRHPGDHSD17B10 | |
| SCHEMBL9153667 | 0.77 | TSHR (0.42) | ALDH1A1TSHRHSD17B10NPSR1MAPT | |
| SCHEMBL9150409 | 0.76 | NPSR1 (0.43) | CYP3A4ALDH1A1TSHRHSD17B10NPSR1 | |
| SCHEMBL30970296 | 0.76 | NPSR1 (0.67) | CYP3A4ALDH1A1NPSR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5475024-A | Useful in treating liver disease | EISAI CO., LTD. (JP) | 1995-12-12 | — | — | US | disclosed |
| US-5292901-A | Benzodioxole derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0281098-B1 | BENZODIOXOLE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME, AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICAMENTS | Eisai Co., Ltd. (JP) | 1992-11-25 | — | — | EP | disclosed |
| US-5110956-A | Liver disorders | EISAI CO., LTD. (JP) | 1992-05-05 | — | — | US | disclosed |
| CN-88101155-A | The preparation of benzo benzodioxole derivatives and application thereof | — | 1988-09-28 | — | — | CN | disclosed |
| EP-0281098-A1 | Benzodioxole derivatives, compositions comprising the same, and the use of the same for the manufacture of medicaments | Eisai Co., Ltd. (JP) | 1988-09-07 | — | — | EP | disclosed |