Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9578546 | 1.00 | TSHR (0.41) | TSHRTTRPDK1PDK2PDK3 | |
| SCHEMBL9578533 | 0.90 | RORC (0.36) | TSHRPDK1PDK2PDK3PDK4 | |
| SCHEMBL9142398 | 0.84 | CA12 (0.54) | TSHRTTRMRGPRX4ALDH1A1RAB9A | |
| SCHEMBL10187728 | 0.83 | CA12 (0.36) | TSHRALDH1A1HSD17B10RAB9ALMNA | |
| SCHEMBL9145702 | 0.79 | TTR (0.46) | TSHRTTRPDK1PDK2PDK3 | |
| SCHEMBL9578550 | 0.79 | TTR (0.46) | TSHRTTRPDK1PDK2PDK3 | |
| SCHEMBL9147212 | 0.78 | TSHR (0.48) | TSHRMRGPRX4ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL9141752 | 0.78 | TSHR (0.48) | TSHRMRGPRX4ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL1014876 | 0.77 | TSHR (0.53) | TSHRTTRMRGPRX4ALDH1A1RAB9A | |
| SCHEMBL9578582 | 0.77 | NPC1 (0.44) | TSHRLMNANPC1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5399701-A | Polyfluoroalkyloxypyridinecarboxylic acid and -carboxaldehyde intermediates | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0255236-B1 | Fluorine-containing chiral smectic liquid crystals | MINNESOTA MINING & MFG (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0360521-B1 | Achiral fluorine-containing liquid crystals | MINNESOTA MINING & MFG (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5254747-A | Fluorine-containing chiral smectic liquid crystals | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1993-10-19 | — | — | US | disclosed |
| US-5082587-A | ACHIRAL FLUORINE-CONTAINING LIQUID CRYSTALS | 3M INNOVATIVE PROPERTIES COMPANY | 1992-01-21 | — | — | US | disclosed |
| EP-0360521-A2 | Achiral fluorine-containing liquid crystals | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1990-03-28 | — | — | EP | disclosed |
| US-4886619-A | TILTED OR LATENT TILTED MESOPHASES; BLENDS; FERROELECTRIC DEVICE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1989-12-12 | — | — | US | disclosed |
| EP-0255236-A2 | Fluorine-containing chiral smectic liquid crystals | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1988-02-03 | — | — | EP | disclosed |